I also run multiple screens. 3 to be exact. On my main (right) screen, I have my browser open with 5 tabs loaded. After that gets going, I start HRD where my Logbook and Rotor are on this main screen which is right in front of my operation position. On the far left screen is my HRD Rig Control. All of those are in full screen mode except for the rotator. On the middle screen is WSJTx at less than full screen and its Waterfall is overlaid on the bottom half of my HRD RC (left most) screen. JTAlert is docked to the top of WSJTx with 3x6 rows, the Macro list is docked to the right of WSJTx. All screens are 1280x1024 since my monitors are 17" square and this configuration works great for me. Everything is functionally and easily readable.
When not running WSJTx modes, I move the RC to the middle screen for ease of access. If I use HRD's DM780 digital software, it's on the right (main) screen in full.
I have used this setup for many years with great ease of use. My computer is a small Dell i5 with 8Gb RAM and a 500Gb SSD. Not a powerhouse for sure. CPU idles at 20% and RAM usage is about 40% with everything active. Totally responsive for all tasks I have running, even when using remote access software to operate from my recliner.
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73's
George - WB5JJJ